Intravenous versus perineural dexamethasone to prolong analgesia after interscalene brachial plexus block: a systematic review with meta-analysis and trial sequential analysis
Pooled resultResult — go to the resultMean difference 122 min 95% CI 62–183Authors' conclusion
There is low-quality evidence that perineural administration of dexamethasone as a local anaesthetic adjunct increases duration of analgesia by an average of 2 h compared with intravenous injection for interscalene brachial plexus block.
Study context
- Population
- Patients receiving interscalene brachial plexus block
- Participants
- 1,145 patients · 11 trials
- Comparison
- Perineural dexamethasone vs Intravenous dexamethasone
- Outcome
- Duration of analgesia (time from block or onset of sensory blockade to first analgesic request or initial report of pain)
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
Mean difference
122 min
95% CI 62–183
P < 0.0001
Perineural dexamethasone vs Intravenous dexamethasone
mean difference 122 min (95% CI 62–183); P < 0.0001
Further pooled results
Secondary outcomes
- No significant differences except onset time of sensory and motor blockade and resting pain score at 12 h; magnitude of differences not clinically relevant
Original publication
Intravenous versus perineural dexamethasone to prolong analgesia after interscalene brachial plexus block: a systematic review with meta-analysis and trial sequential analysis. Br J Anaesth. Published 23 May 2024. doi:10.
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