Intravenous versus oral acetaminophen for pain and quality of recovery after ambulatory spine surgery: a randomized controlled trial
Authors' conclusion
Intravenous acetaminophen was not superior to the oral form in ambulatory spine surgery patients.
Study context
- Population
- Patients undergoing ambulatory spine surgery under GA with multimodal analgesiaincluded in final analyses
- Participants
- 82 patients
- Comparison
- IV vs oral acetaminophen
- Primary endpoint
- Opioid use in IV MME, beginning with arrival to PACU
- Follow-up
- 24 hours
Methodological detailsplacebo-controlled
- Placebo-controlled
Primary result
As reported in the abstract
24-hour opioid use (IV MME), from PACU arrival
- Intravenous acetaminophen vs Oral acetaminophen: P = 0.893
- Group order of the values as in the abstract (intravenous vs oral)
Secondary outcomes
Postoperative pain, postanesthesia care unit (PACU) MME, QoR-15, recovery time
- No differences between groups
Correlation of postoperative opioid use with QoR-15
- Moderate negative correlation (Spearman)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Intravenous versus oral acetaminophen for pain and quality of recovery after ambulatory spine surgery: a randomized controlled trial. Reg Anesth Pain Med. Published 18 March 2024. doi:10.
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