Cardiothoracic & vascular anesthesia
Introduction of a Vendor-Independent Application for Clinical Generation of Pressure-Volume Loops from Routine Hemodynamic Data: A Methodological Exploration
Authors' conclusion
This study introduces a vendor-independent application to generate PVLs from routinely available clinical data.
Study context
- Population
- Adults undergoing elective cardiac surgery, single university teaching hospital; Right ventricular (RV) data, plus biventricular simulated data (Harvi simulator)elective cardiac surgery
- Participants
- 12 adults
- Exposure
- Supine baseline vs passive leg raise, elevated positive end-expiratory pressure (PEEP) and after chest wall opening
- Outcome
- Overall PVL feasibility (combining 3 acquisitions)
Methodological detailssingle-centre, methodological exploration, simulated and clinical data
- Single-centre
- Methodological exploration
- Simulated and clinical data
Main finding
As reported in the abstract
Overall PVL feasibility combining 3 acquisitions
Overall pressure-volume loop (PVL) feasibility combining 3 acquisitions
97.6%
Observational data: associations, not effects.
Further findings
| Outcome | Change (%) | P value |
|---|---|---|
| End-diastolic volume, leg raiseLeg raise vs Baseline | +36 ± 23 | P = 0.0054 |
| Stroke volume, leg raiseLeg raise vs Baseline · stable HR | +32 ± 27 | P = 0.017 |
| CO, leg raiseLeg raise vs Baseline · trend toward increase | +34 ± 33 | P = 0.06 |
| Arterial elastance, PEEPPEEP vs other conditions · marked increase | +126 ± 80 | P = 0.0000068 |
PVL parameters, chest opening
- Chest opening resulted in minor effects
Original publication
Introduction of a Vendor-Independent Application for Clinical Generation of Pressure-Volume Loops from Routine Hemodynamic Data: A Methodological Exploration. J Cardiothorac Vasc Anesth. Published 26 November 2024. doi:10.
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