Investigating Deep Sedation With Intravenous Ketamine in Spontaneous Respiration During Pulsed-Field Ablation
Authors' conclusion
The authors' standardized sedation protocol with the administration of drugs with rapid onset and pharmacologic offset at low doses was safe and effective, with an optimal degree of patient and operator satisfaction.
Study context
- Population
- Consecutive patients undergoing pulsed-field ablation (PFA) of atrial fibrillation (AF), single centre
- Participants
- 117 patients
- Outcome
- Sedation effectiveness and satisfaction (Ramsay Sedation Scale, patient and operator satisfaction, NRS pain)
Methodological detailsnonrandomized, single-centre
- Nonrandomized
- Single-centre
Main finding
As reported in the abstract
- Mean time under sedation (min)
- 54.9 ± 6
- Sedated for <1 hour
- 92 patients (79%)
- Satisfactory Ramsay Sedation Scale level before ketamine, all patients except one; rank 3
- 80.3%
- Ramsay Sedation Scale rank 2
- 18.4%
- Satisfaction satisfactory (patient and primary operator)
- 98.2%
Observational data: associations, not effects.
Safety
- No major procedure or anesthesia-related complications reported
Original publication
Investigating Deep Sedation With Intravenous Ketamine in Spontaneous Respiration During Pulsed-Field Ablation. J Cardiothorac Vasc Anesth. Published 20 October 2023. doi:10.
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