Perioperative medicine & outcomes
Is chronic inflammation a risk factor for perioperative myocardial injury or heart failure in pancreatic surgery patients?
Authors' conclusion
Preoperative inflammation was not associated with PMI or postoperative biomarkers of heart failure after pancreatic surgery.
Study context
- Population
- Pancreatic surgery patients
- Participants
- 88 patients
- Exposure
- High vs normal preoperative IL-6
- High IL-6n = 24
- Outcome
- Perioperative myocardial injury (PMI): absolute hs-cTnT increase ≥14 pg ml-1
Main finding
As reported in the abstract
PMI (absolute hs-cTnT increase ≥14 pg ml-1)
- High IL-6 vs Normal IL-6: P = 0.86
- Two (8.3%) and eight (12.5%) patients with high and normal concentrations, respectively
Observational data: associations, not effects.
Secondary outcomes
Preoperative hs-cTnT · before surgery
P = 0.01
Preoperative GDF-15 · before surgery
P = 0.021
Preoperative NT-proBNP · before surgery
P = 0.012
Postoperative biomarkers (high-sensitive cardiac troponin-T (hs-cTnT), GDF-15, NT-proBNP) · 4, 12, 24, and 48 h after surgery
- All biomarkers increased after surgery
- all P<0.05
- Increase similar in high vs normal preoperative IL-6
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Is chronic inflammation a risk factor for perioperative myocardial injury or heart failure in pancreatic surgery patients? BJA Open. Published 19 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →