Respiratory failure & ventilation
Is Electrical Impedance Tomography (EIT)-guided positive end-expiratory pressure titration for optimizing PEEP in ARDS the white elephant in the room? A systematic review with meta-analysis and trial sequential analysis
Authors' conclusion
EIT-guided individualized PEEP titration is a novel modality
Study context
- Population
- Adult ARDS patients
- Participants
- 515 patients · 5 cohort studies · 2 RCTs
- Comparison
- EIT-guided PEEP titration vs conventional methods
- Outcome
- Mortality
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
Overall reduced risk of mortality with EIT-guided PEEP titration: RR
0.68
95% CI 0.49 to 0.95; I2 = 0%
Further pooled results
Dynamic compliance
- Better dynamic compliance with EIT-guided PEEP titration: MD
- 3.46 (95% CI 1.59 to 5.34; I2 = 0%)
- Required information size achieved (trial sequential analysis)
PaO2/FiO2 ratio
- No significant difference in PaO2/FiO2 ratio: MD
- 6.5 (95% CI −13.86 to 26.76; I2 = 74%)
- Required information size not achieved (trial sequential analysis)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Is EIT-guided positive end-expiratory pressure titration for optimizing PEEP in ARDS the white elephant in the room? A systematic review with meta-analysis and trial sequential analysis. J Clin Monit Comput. Published 15 April 2024. doi:10.
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