Neuroanesthesia & neurocritical care
Is ketamine safe for traumatic brain injury? A systematic review and meta-analysis
Pooled result · Hospital mortalityResult — go to the resultRelative risk 1.18 95 % CI 0.90–1.55Study context
- Population
- Patients with traumatic brain injury (TBI) receiving ketamine for tracheal intubation or analgosedation15 studies · 4 RCTs
- Comparison
- Ketamine vs other anesthetic agents or placebo
- Outcome
- Hospital mortality
Methodological detailsPRISMA methodology
- PRISMA methodology
Pooled result
As reported in the abstract
Relative risk
1.18
95 % CI 0.90–1.55
P = 0.23
Between groups
RR 1.18 (95 % CI 0.90–1.55); P = 0.23
Further pooled results
| Outcome | RR (95 % CI) | P value | |
|---|---|---|---|
| ICP elevation (baseline ICP < 20 mmHg)I2 = 0.0 % | 0.67 (0.45–1.01) | P = 0.054 | |
| 0.512Relative risk (log scale) |
Safety
| Outcome | RR (95 % CI) | P value | |
|---|---|---|---|
| Hypotension episodesI2 = 0.0 % | 1.47 (1.22–1.78) | P < 0.01 | |
| 0.512Relative risk (log scale) |
Original publication
Is ketamine safe for traumatic brain injury? A systematic review and meta-analysis. J Crit Care. Published 5 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →