ICU sedation, delirium & recovery
Isolated diastolic dysfunction is associated with increased mortality in critically ill patients
Authors' conclusion
Isolated diastolic dysfunction, assessed by a multi-parameter approach, is common in critically ill patients and is associated with mortality.
Study context
- Population
- ICU patients with normal left ventricular (LV) function (no reduced LV ejection fraction, regional wall motion abnormality or history of cardiac disease), echocardiography within 24 h of ICU admission
- Participants
- 218 patients
- Comparison
- Diastolic dysfunction or indeterminate diastolic function vs normal diastolic function (2016 EACVI guidelines)
- Normal diastolic functionn = 162reference
- Diastolic dysfunctionn = 21
- Indeterminate diastolic functionn = 35
- Primary endpoint
- Death
- Follow-up
- 90 days
Methodological detailssingle-centre, risk-adjusted logistic regression, Patients classified by the 2016 EACVI guidelines for evaluation of LV diastolic function by echocardiography
- Single-centre
- Risk-adjusted logistic regression
- Patients classified by the 2016 EACVI guidelines for evaluation of LV diastolic function by echocardiography
Primary result
As reported in the abstract
Risk of death
Each group vs normal diastolic functionOdds ratio (CI)P value
Indeterminate diastolic function
4.3(1.6–11.4)
P = 0.004Diastolic dysfunction
5.1(1.6–16.5)
P = 0.006Further findings
Prevalence of diastolic function categories
Characteristics associated with diastolic dysfunction
- More common in female and older patients; associated with sepsis, respiratory and cardiovascular comorbidity and higher SAPS score
Original publication
Isolated diastolic dysfunction is associated with increased mortality in critically ill patients. J Crit Care. Published 20 March 2023. doi:10.
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