Hemodynamics, fluids & transfusion
Lactate Values and Mortality in Patients With Cardiogenic Shock: Insights From the Altshock-2 Registry
Authors' conclusion
Higher baseline and 24-hour lactates were both independently associated with increased in-hospital mortality in patients with CS, although the 24-hour value had a higher predictive accuracy.
Study context
- Population
- Consecutive patients with cardiogenic shock (CS) and available lactate data, Italian Altshock-2 Registry (12 centres), since March 2020
- Participants
- 651 patients · 12 centres
- Exposure
- Baseline vs 24-hour plasma lactates as predictors of in-hospital mortality
- Lactate <2.0 mmol/Ln = 248
- Lactate 2.1-4.0 mmol/Ln = 172
- Lactate >4.0 mmol/Ln = 231
- Outcome
- In-hospital mortality
Methodological detailsmulticentre, consecutive patients, Mean age 64 ± 14 years; 76% male
- Multicentre
- Consecutive patients
- Mean age 64 ± 14 years; 76% male
Main finding
As reported in the abstract
In-hospital mortality per 1-mmol/L lactate increase
Adjusted odds ratio (95% CI)
Baseline lactate (per 1-mmol/L increase)
1.08(1.02–1.14)
24-hr lactate (per 1-mmol/L increase)
1.37(1.15–1.63)
Per 1-mmol/L increase, as printed
- AUC for mortality, 24-hour lactate
- 0.702
- AUC for mortality, baseline lactate
- 0.648
- Optimal baseline lactate cutoff for predicting mortality (mmol/L)
- 3.2
- Optimal 24-hour lactate cutoff for predicting mortality (mmol/L)
- 1.7
Observational data: associations, not effects.
Further findings
Lactate improvement at 24 hours
- Patients with improved lactate values
- 76.5%
Optimal lactate cutoffs in patients treated with mechanical circulatory support (MCS)
- Cutoffs varied in patients treated with MCS at different time points
Original publication
Lactate Values and Mortality in Patients With Cardiogenic Shock: Insights From the Altshock-2 Registry. Crit Care Med. Published 12 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →