Liposomal Bupivacaine for Peripheral Nerve Blockade: A Randomized, Controlled, Crossover, Triple-blinded Pharmacodynamic Study in Volunteers
Authors' conclusion
The results show that liposomal bupivacaine is not a suitable "sole" drug for intraoperative regional anesthesia.
Study context
- Population
- Volunteers aged 18 to 55 yr (BMI 18 to 35 kg/m²)crossover
- Participants
- 25 vs 25
- Comparison
- Liposomal vs plain bupivacaine for ultrasound-guided ulnar nerve block
- Liposomal bupivacainen = 25
- Plain bupivacainen = 25reference
Methodological detailscrossover, triple-blinded, single-center, volunteers
- Crossover
- Triple-blinded
- Single-center
- Volunteers
Primary result
As reported in the abstract
Successful sensory blockade
P < 0.0001
Further findings
| Outcome | P value |
|---|---|
| Time to onset (0% response to pinpricking in four of five hypothenar areas) | P < 0.0001 |
| Time from onset to 80% or 20% in one of five areas80% and 20%: P < 0.001 each | P < 0.001 |
Time to onset (0% response to pinpricking in four of five hypothenar areas)
- Significant difference
Time from onset to 80% or 20% in one of five areas
- Significant differences
Carryover effects of randomized sequencing
- Carryover effects unlikely; estimate
- −0.6286
- Sequence effect
- 0.8772
- P
- P = 0.474
Residual sensory blockade (self-assessment diary) · greater than 3.5 days
- Intermittent but unpredictable episodes of residual sensory blockade, for liposomal bupivacaine only
Original publication
Liposomal Bupivacaine for Peripheral Nerve Blockade: A Randomized, Controlled, Crossover, Triple-blinded Pharmacodynamic Study in Volunteers. Anesthesiology. Published 1 April 2024. doi:10.
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