The postoperative analgesic efficacy of liposomal bupivacaine versus long-acting local anaesthetics for peripheral nerve and field blocks: A systematic review and meta-analysis, with trial sequential analysis
Pooled resultResult — go to the resultMean difference −0.9 95% CI −1.4 to −0.4Authors' conclusion
There is moderate level evidence that liposomal bupivacaine reduces rest pain scores by 0.9 out of 10 units, when compared with long-acting local anaesthetics at 24 hours after surgery, and by 0.7 up to 72 hours after surgery.
Study context
- Population
- Patients receiving peripheral nerve and field blocks after all types of surgery
- Participants
- 2,122 patients · 27 RCTs
- Comparison
- Liposomal bupivacaine vs Long-acting local anaesthetics
- Outcome
- Rest pain score (analogue scale 0 to 10)
- Follow-up
- 24 h
Methodological detailstrial sequential analysis, Quality of evidence moderate
- Trial sequential analysis
- Quality of evidence moderate
Pooled result
As reported in the abstract
Mean difference
−0.9
95% CI −1.4 to −0.4
P < 0.001
Liposomal bupivacaine vs Long-acting local anaesthetics
mean difference −0.9 (95% CI −1.4 to −0.4); P < 0.001
Further pooled results
| Outcome | Mean difference (95% CI) | P value | |
|---|---|---|---|
| Rest pain score · 48 hI2 = 82% | −0.7 (−1.1 to −0.3) | P = 0.001 | |
| Rest pain score · up to 72 hI2 = 80% | −0.7 (−1.1 to −0.3) | P < 0.001 | |
| −1.5−1−0.500.5Difference (linear scale) |
Interval morphine consumption · 24, 48 and 72 h
- No differences at 24 h
- P = 0.15
- No differences at 48 h
- P = 0.15
- No differences at 72 h
- P = 0.07
Original publication
The postoperative analgesic efficacy of liposomal bupivacaine versus long-acting local anaesthetics for peripheral nerve and field blocks: A systematic review and meta-analysis, with trial sequential analysis. Eur J Anaesthesiol. Published 10 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →