Cardiothoracic & vascular anesthesia
Long-Term Coronary Microvascular and Cardiac Dysfunction After Severe COVID-19 Hospitalization
An erratum to this article was published (JAMA Netw Open, 1 Jul 2025 ↗)
Authors' conclusion
In this study, patients with COVID-19 exhibited long-term reduced stress perfusion indicating CMD, along with declined left ventricular function by global longitudinal strain and global circumferential strain.
Study context
- Population
- Patients previously hospitalized due to severe COVID-19, from the prospective UppCov study, with perfusion cardiovascular magnetic resonance (CMR) at 10 months after discharge
- Participants
- 37 vs 22
- Comparison
- Patients after severe COVID-19 hospitalization vs healthy volunteers
- COVID-19n = 37
- Healthy volunteersn = 22reference
- Outcome
- Long-term LV function and presence of coronary microvascular dysfunction (CMD) by comprehensive CMR (native T1, native T2, extracellular volume, adenosine stress and rest perfusion mapping, gadolinium enhancement, cine imaging)
- Follow-up
- 10 months after discharge
Methodological detailssingle-centre, sex- and age-matched historical controls
- Single-centre
- Sex- and age-matched historical controls
Main finding
As reported in the abstract
Mean stress perfusion
P = 0.003
Observational data: associations, not effects.
Further findings
Mean
| Outcome | COVID-19 | Healthy volunteers | P value |
|---|---|---|---|
| Mean global longitudinal strainImpaired in COVID-19 | −17% (95% CI −18%–-16%) | −19% (95% CI −20%–-18%) | P = 0.003 |
| Mean global circumferential strainImpaired in COVID-19 | −16% (95% CI −17%–-15%) | −19% (95% CI −20%–-18%) | P = 0.001 |
Stress perfusion and myocardial perfusion reserve within COVID-19 (subgroup: with vs without cardiovascular risk factors or cardiac symptoms)
- No differences between patients with vs without cardiovascular risk factors or cardiac symptoms
Original publication
Long-Term Coronary Microvascular and Cardiac Dysfunction After Severe COVID-19 Hospitalization. JAMA Netw Open. Published 2 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →