Lost in Translation: Failure of Preclinical Studies to Accurately Predict the Effect of Regional Analgesia on Cancer Recurrence
Authors' conclusion
Both basic scientists and clinical investigators underestimated the limitations of various preclinical models, leading to the apparently incorrect hypothesis that regional anesthesia reduces cancer recurrence.
Study context
- Population
- Patients having surgery for breast, lung and abdominal cancers
- Participants
- 4,770 randomised trials
- Comparison
- Regional analgesia vs no regional analgesia for cancer recurrence
- Outcome
- Survival outcomes after breast, lung and abdominal cancers
Main finding
As reported in the abstract
- Regional analgesia does not improve survival outcomes after breast, lung and abdominal cancers in randomised trials, despite preclinical evidence suggesting benefit
Original publication
Lost in Translation: Failure of Preclinical Studies to Accurately Predict the Effect of Regional Analgesia on Cancer Recurrence. Anesthesiology. Published 3 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →