Perioperative medicine & outcomes

Low intraoperative end-tidal carbon dioxide levels are associated with improved recurrence-free survival after elective colorectal cancer surgery

J Clin AnesthPublished Retrospective cohort study

Authors' conclusion

Lower intraoperative EtCO2 target values in CRC surgery might benefit oncological outcome

Study context

Population
Patients undergoing elective colorectal cancer resection at Heidelberg University Hospital, 2009–2018median follow-up 3.8 years
Participants
528 patients
Exposure
Low vs high intraoperative EtCO2
Outcome
Recurrence-free survival until last known follow-up
Methodological detailssingle-centre
  • Single-centre

Main finding

As reported in the abstract

Recurrence-free survival · until last known follow-up

P = 0.024

Observational data: associations, not effects.

Secondary outcomes

1-year and 5-year survival

Higher in the low-EtCO2 group

Sepsis, reoperations, surgical site infections, cardiovascular events during hospital stay

No differences

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Low intraoperative end-tidal carbon dioxide levels are associated with improved recurrence-free survival after elective colorectal cancer surgery. J Clin Anesth. Published 10 May 2024. doi:10.1016/j.jclinane.2024.111495

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