Cardiothoracic & vascular anesthesia
Low postoperative mitochondrial oxygen tension is an early marker of acute kidney injury after cardiac surgery: A prospective observational study
Authors' conclusion
A mitoPO2 value below 30 mmHg at ICU admission as well as the duration below this threshold indicate the development of AKI in cardiac surgery patients, occurring earlier than an increase in lactate above the normal range.
Study context
- Population
- Patients undergoing cardiac surgery44 with analyzable mitoPO2
- Participants
- 50 patients
- Exposure
- Acute kidney injury (AKI) vs no AKI after cardiac surgery
- AKIn = 5
- Outcome
- Postoperative mitoPO2 as an early marker of AKI (KDIGO)
- Follow-up
- ICU admission
Main finding
As reported in the abstract
MitoPO2 at ICU admission
P < 0.001
- MitoPO2 predicted AKI (ROC)
- 0.95 (0.89-1.0)
- Optimal cut-off
- 30 mmHg
- OR at cut-off
- 4.4, CI 2.8-6.0, p < 0.001
Observational data: associations, not effects.
Further findings
Time under mitoPO2 threshold predicting AKI
- AUROC
- 0.91(0.80-1.00)
Timing vs serum lactate
- Decreased mitoPO2 occurred earlier than clinically relevant lactate increase, all patients
- 4 h
Other markers of tissue hypoperfusion
- Did not differ between AKI and no AKI
Original publication
Low postoperative mitochondrial oxygen tension is an early marker of acute kidney injury after cardiac surgery: A prospective observational study. J Crit Care. Published 22 April 2025. doi:10.
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