Neuroanesthesia & neurocritical care
The lower limit of reactivity as a potential individualised cerebral perfusion pressure target in traumatic brain injury: a CENTER-TBI high-resolution sub-study analysis
Authors' conclusion
Using a multicentre cohort, we confirmed that CPP below LLR was associated with mortality during the first seven days post injury.
Study context
- Population
- Traumatic brain injury (TBI) patients from the high-resolution cohort of the CENTER-TBI study
- Participants
- 171 patients
- Comparison
- %time with cerebral perfusion pressure (CPP) below the individual lower limit of reactivity (LLR), survivors vs non-survivors
- Primary endpoint
- Mortality, by %time with CPP < LLR
- Follow-up
- First 7 days
Methodological detailsobservational cohort study, multicentre, validation study
- Observational cohort study
- Multicentre
- Validation study
Primary result
As reported in the abstract
Prediction of mortality by %time with CPP < LLR
AUC of %time with CPP < LLR for mortality
0.73
P value
p = < 0.001
Further findings
Average LLR over the first 7 days above 60 mmHg
- Proportion of patients with average LLR above 60 mmHg
- 48%
Daily association of %time with CPP < LLR with mortality · daily analysis for 7 days
- Association becomes significant starting from the third day post injury
Association of %time with CPP < LLR with mortality, adjusted
- Relationship maintained when correcting for IMPACT covariates or for high ICP
Original publication
The lower limit of reactivity as a potential individualised cerebral perfusion pressure target in traumatic brain injury: a CENTER-TBI high-resolution sub-study analysis. Crit Care. Published 20 May 2023. doi:10.
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