Respiratory failure & ventilation
Lung-protective ventilation during Trendelenburg pneumoperitoneum surgery: A randomized clinical trial
Authors' conclusion
In obese patients undergoing Trendelenburg pneumoperitoneum surgery, PV did not improve postoperative oxygenation nor day-2 respiratory function.
Study context
- Population
- Morbidly obese patients undergoing Trendelenburg pneumoperitoneum gynaecological surgery, university hospital, Italyanalysed
- Participants
- 60 patients
- Comparison
- Protective vs standard ventilation during anaesthesia
- SVn = 31reference
- PVn = 29
- Primary endpoint
- PaO2/FiO2
- Follow-up
- One hour after extubation
Methodological detailsparallel-group, single-centre
- Parallel-group
- Single-centre
Primary result
As reported in the abstract
P = 0.64
Secondary outcomes
Tidal volume
End-expiratory lung volume (EELV) · intraoperative
P = 0.80
Airway driving pressure · intraoperative
P < 0.001
PaCO2 · intraoperative
P < 0.001
Respiratory rate · intraoperative
P < 0.001
| Outcome | SV | PV | P value |
|---|---|---|---|
| Transpulmonary driving pressure · intraoperative | 13 ± 7 | 9 ± 4 | P < 0.001 |
| Ratio of tidal volume to EELV (lower in PV) · intraoperativePrinted: 0.45 ± 0.12 vs. 0.32 ± 0.09 | P < 0.001 |
Day-1 PaO2/FiO2; day-2 FVC, FEV-1, Tiffenau Index
- Not different between groups
- all p > 0.10
Complete airway closure during pneumoperitoneum · intraoperative
- Patients with complete airway closure, no difference between groups
- 59%
- Median airway opening pressure (cmH2O)
- 17
Original publication
Lung-protective ventilation during Trendelenburg pneumoperitoneum surgery: A randomized clinical trial. J Clin Anesth. Published 7 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →