Cardiothoracic & vascular anesthesia
Maintenance of beta-blockers and cardiac surgery-related outcomes: a prospective propensity-matched multicentre analysis
Main finding · Postoperative AFResult — go to the resultOdds ratio 0.86 95% CI 0.66–1.14Authors' conclusion
Maintenance of beta-blockers on the day of surgery was not associated with a reduced incidence of postoperative atrial fibrillation.
Study context
- Population
- Patients treated with beta-blockers undergoing cardiac surgery583 matched per group
- Participants
- 1,789 patients
- Exposure
- Maintenance vs no maintenance of beta-blockers on the day of surgery
- Maintenancen = 583
- No maintenancen = 583reference
- Outcome
- Postoperative AF and acute kidney injury (AKI) after cardiac surgery
Methodological detailspropensity-matched, multicentre
- Propensity-matched
- Multicentre
Main finding
Postoperative AF
Odds ratio
0.86
95% CI 0.66–1.14
P = 0.335
Events by group
Maintenance vs No maintenance
OR 0.86 (95% CI 0.66–1.14); P = 0.335
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Postoperative AF (sensitivity analysis) | 0.93 (0.72–1.22) | P = 0.625 | |
| 0.512Odds ratio (log scale) |
Postoperative AKI · higher rate with maintenance
P = 0.0127
Norepinephrine use · higher rate with maintenance
P = 0.0001
ICU LOS
- No statistically significant difference
Original publication
Maintenance of beta-blockers and cardiac surgery-related outcomes: a prospective propensity-matched multicentre analysis. Br J Anaesth. Published 23 May 2024. doi:10.
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