Mean flow index (Mxa) algorithm option can influence cerebral autoregulation classification in critically ill septic patients
Authors' conclusion
Mxa values calculated using different combinations of block, overlap, and epoch duration were consistent within patients, particularly when epoch length was maintained.
Study context
- Population
- Septic shock patients, TCD recordings within 48 h of ICU admission
- Participants
- 50 TCD recordings
- Exposure
- Mxa computed with different block, overlap and epoch configurations
- Outcome
- Reproducibility of Mxa across calculations with variable blocks, overlap periods and epochs
Methodological detailsreproducibility analysis, eight signal-processing configurations
- Reproducibility analysis
- Eight signal-processing configurations
Main finding
As reported in the abstract
Mxa agreement across configurations
- Median Mxa range across configurations
- 0.36 to 0.45
- No significant within-patient differences
- p > 0.05
- Intraclass correlation coefficients (ICC) between approaches with same epoch duration
- ICC > 0.90
- ICC between 3-10-50 and 5-10-50 (different epoch lengths)
- ICC = 0.782
Observational data: associations, not effects.
Original publication
Mean flow index (Mxa) algorithm option can influence cerebral autoregulation classification in critically ill septic patients. J Clin Monit Comput. Published 8 December 2025. doi:10.
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