Profiling cerebral hemodynamics in sepsis and septic shock patients with transcranial doppler: a systematic review and meta-analysis
Authors' conclusion
Cerebral hemodynamics are often altered in sepsis and septic shock and may contribute to neurological alterations observed in such patients.
Study context
- Population
- Patients with sepsis or septic shock assessed with transcranial Doppler (TCD)
- Participants
- 1,087 patients · 29 studies
- Outcome
- Cerebral hemodynamics on TCD
Pooled result
As reported in the abstract
- Mean MCA velocity within normal limits
- Cerebral perfusion pressure relatively low, without increase in estimated ICP
- Cerebral autoregulation often impaired
- Cerebral vasoreactivity: divergent results
Further pooled results
- Pulsatility index and impaired autoregulation associated with occurrence of neurological dysfunction
Original publication
Profiling cerebral hemodynamics in sepsis and septic shock patients with transcranial doppler: a systematic review and meta-analysis. J Clin Monit Comput. Published 5 December 2025. doi:10.
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