Median effective dose of ropivacaine for prophylactic cervical cerclage in Chinese women: a dose-finding study
Authors' conclusion
The ED50 of intrathecal ropivacaine for prophylactic cervical cerclage was 6.9 mg. Intrathecal ropivacaine (7.8 mg) is likely to produce successful anaesthesia in 95% of patients undergoing prophylactic cervical cerclage.
Study context
- Population
- Chinese women scheduled for prophylactic cervical cerclage under combined spinal-epidural (CSE) anaesthesia in the first or second trimester
- Participants
- 40 women
- Outcome
- ED50 of intrathecal ropivacaine (effective block not lower than T12)
Methodological detailsup-and-down sequential allocation (0.5 mg steps), isotonic regression
- Up-and-down sequential allocation (0.5 mg steps)
- Isotonic regression
Main finding
As reported in the abstract
ED50 of intrathecal isobaric ropivacaine
ED50 (isotonic regression), 95% CI 6.68 to 7.12 mg
6.9 mg
Secondary outcomes
Calculated ED95
- ED95, 95% CI 7.69 to 10.05 mg
- 7.8 mg
Block success
- Effective block with intrathecal ropivacaine only
- 23 (57.5%) of 40
- Needed extra epidural lidocaine
- 17 (42.5%)
Time to resolution of sensory and motor block (intrathecal ropivacaine alone)
- Sensory block resolution, min
- 90 (75-100)
- Motor block resolution, min
- 90 (60-100)
Original publication
Median effective dose of ropivacaine for prophylactic cervical cerclage in Chinese women: a dose-finding study. Reg Anesth Pain Med. Published 30 December 2022. doi:10.
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