Pediatric anesthesia & critical care
Metabolic Alkalosis in the Pediatric Cardiac Intensive Care Unit—A Prospective Observational Study
Authors' conclusion
This prospective study on postcardiotomy infants revealed a much lower incidence of metabolic alkalosis than historical data. Physicochemical analysis of the blood samples for mechanisms underlying metabolic alkalosis found that its development is not entirely dependent on overt volume depletion or significant chloride loss. The administration of chloride-containing solutions appears to mitigate both the occurrence and severity of metabolic alkalosis.
Study context
- Population
- Infants <1 year undergoing elective cardiac surgery requiring >6 h postoperative mechanical ventilation, pediatric cardiac ICU, tertiary teaching hospital in India, 2020–2021
- Participants
- 104 infants
- Exposure
- Infants who developed metabolic alkalosis vs those who did not
- MAn = 23
- Outcome
- Incidence of metabolic alkalosis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
MA
22.1%
23
Observational data: associations, not effects.
Further findings
Application of modified ultrafiltration (MUF)
P = 0.005
| Outcome | MA | No MA | Estimate | P value |
|---|---|---|---|---|
| RACHS-1 category 3 and above | 73.9% | — not stated in the abstract | P = 0.009 | |
| CPB time | 200.04 ± 83.35 min | 144.59 ± 64.77 | (95% CI 23–87.9) | |
| Cross-clamp time | 119.78 ± 63.12 min | 84.95 ± 48.8 | (95% CI 10.4–59.3) | |
| Volume of MUF removed | 60 (interval 44.4–70) ml kg-1 | 44.44 (interval 32.9–54.3) | P = 0.003 | |
| Standard base excess due to free water (SBEFW) | −0.18 ± 0.94 | 0.25 ± 1.1 | (CI −0.95 to 0.09) | |
| Standard base excess due to chloride (SBECl) | −5.7 ± 4.8 | −5.18 ± 5.05 | (95% CI −2.9 to 1.8) |
— not stated in the abstract
Standard base excess due to free water (SBEFW)
- Similar in both groups
Standard base excess due to chloride (SBECl)
- Similar in both groups
Ventilation duration, ICU stay, hospital stay
- Longer in group MA
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →