Mitochondrial regulation of lactylation in sepsis-induced cardiomyopathy
Study context
- Population
- Sepsis-induced cardiomyopathy (SICM)
Methodological detailsSynthesises evidence on mitochondrial regulation of lactylation in SICM, molecular pathways and potential therapeutic interventions, integrating preclinical and clinical studies
- Synthesises evidence on mitochondrial regulation of lactylation in SICM, molecular pathways and potential therapeutic interventions, integrating preclinical and clinical studies
Main finding
As reported in the abstract
- Mitochondrial dysfunction (metabolic reprogramming, oxidative stress, calcium dysregulation) is a central feature and putative driver of SICM
- Lactylation, a lactate-derived posttranslational modification, identified as a key mechanism amplifying inflammatory and metabolic dysfunction
Original publication
Mitochondrial regulation of lactylation in sepsis-induced cardiomyopathy. Crit Care. Published 17 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →