Cardiothoracic & vascular anesthesia
Mitral Valve Repair in Patients with Chronic Kidney Disease: Long-Term Outcomes and Cardiac Remodeling
Authors' conclusion
In patients with CKD undergoing MVr, eGFR is a predictor of decreased long-term survival and residual mitral regurgitation at 1 year.
Study context
- Population
- Patients with varying stages of chronic kidney disease (CKD) undergoing surgical mitral valve repair, 2004–2018
- Exposure
- Groups by estimated glomerular filtration (eGFR)
- Outcome
- All-cause mortality
Methodological detailsobservational, comparative, single-centre
- Observational
- Comparative
- Single-centre
Main finding
As reported in the abstract
All-cause mortality per 10-unit increase in eGFR
Per 10-unit eGFR increaseHazard ratio (95% CI)P value
5 years
0.81(0.67–0.98)
P = 0.02810 years
0.82(0.72–0.94)
P = 0.00415 years
0.78(0.69–0.88)
P < 0.001Per 10-unit eGFR increase, as printed
Observational data: associations, not effects.
Secondary outcomes
All-cause mortality, moderate CKD · 15 years
| HR (95% CI) | P value | ||
|---|---|---|---|
| Moderate CKD | 3.38 (1.28–8.98) | P = 0.014 | |
| 0.10.31310Hazard ratio (log scale) |
Residual moderate-to-severe mitral regurgitation (eGFR as predictor) · 1 year
| HR (95% CI) | P value | ||
|---|---|---|---|
| eGFR | 0.74 (0.57–0.96) | P = 0.024 | |
| 0.512Hazard ratio (log scale) |
Cardiac remodeling
- Significant reduction in left ventricular size and left atrium volume after mitral valve repair (MVr)
Original publication
Mitral Valve Repair in Patients with Chronic Kidney Disease: Long-Term Outcomes and Cardiac Remodeling. J Cardiothorac Vasc Anesth. Published 28 March 2024. doi:10.
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