Modified Cuff Leak Test for Predicting the Risk of Reintubation in Patients With Invasive Mechanical Ventilation: A Multicenter, Single-Anonymized, Randomized Controlled Trial
Authors' conclusion
Compared with the control group, the modified CLT approach might better predict PES within 24 hours of extubation, especially for patients with IMV duration longer than 6 days, but it was not shown to decrease the reintubation incidence and mortality.
Study context
- Population
- Patients with invasive mechanical ventilation undergoing extubationrandomized
- Participants
- 536 patients
- Comparison
- Modified cuff leak test vs traditional approach
- Modified cuff leak test (CLT)n = 268
- Controln = 268reference
- Primary endpoint
- Incidence of the need for reintubation
- Follow-up
- Within 48 hours of extubation
Methodological detailsprospective, multicentre
- Prospective
- Multicentre
Primary result
As reported in the abstract
Reintubation within 48 hours of extubation · 48 hours
- Did not differ between the groups
Secondary outcomes
| Outcome | Modified CLT | Control | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Postextubation stridor (PES) · within 24 hours of extubationMore frequent in the modified CLT group | 5.22% | 1.49% | 0.275 (0.089–0.846) | P = 0.028 | |
| Duration of invasive mechanical ventilationShorter in the modified CLT group | 137 (interval 74–218) hours | 159 (interval 95–252) hours | 1.001 (1.000–1.002) | P = 0.046 | |
| PES, patients with IMV duration ≥ 6 days (subgroup) | 2.95% | 0.74% | 0.203 (0.042–0.975) | P = 0.048 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Modified Cuff Leak Test for Predicting the Risk of Reintubation in Patients With Invasive Mechanical Ventilation: A Multicenter, Single-Anonymized, Randomized Controlled Trial. Chest. Published 6 February 2025. doi:10.
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