Modulation of Metabolomic Profile in Sepsis According to the State of Immune Activation
Authors' conclusion
Findings suggest distinct metabolic dysregulation patterns associated with different immune dysfunctions in sepsis: the strongest metabolic dysregulation is associated with MALS.
Study context
- Population
- Patients meeting Sepsis-3 definitions with lung infection, acute cholangitis or primary bacteremia, 14 clinical sites in Greece14 sites in Greece
- Participants
- 210 patients
- Comparison
- Macrophage-activation-like syndrome (MALS) vs Immunoparalysis vs Unclassified
Methodological detailsuntargeted metabolomics, multicentre
- Untargeted metabolomics
- Multicentre
Primary result
As reported in the abstract
Plasma metabolites (untargeted metabolomics, 1394 products)
Significantly different metabolites across the immune states
221
Significantly different metabolites, MALS vs unclassified (enrichment in multiple pathways)
312
Differentially regulated metabolites, immunoparalysis vs unclassified
2
Original publication
Modulation of Metabolomic Profile in Sepsis According to the State of Immune Activation. Crit Care Med. Published 23 August 2024. doi:10.
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