Hemodynamics, fluids & transfusion
Monitoring of Argatroban in Critically Ill Patients: A Prospective Study Comparing Activated Partial Thromboplastin Time, Point-of-Care Viscoelastic Testing with Ecarin Clotting Time and Diluted Thrombin Time to Mass Spectrometry
Authors' conclusion
Although activated PTT monitoring of argatroban is the most commonly used test, in critically ill patients, diluted TT provides more precise measurements.
Study context
- Population
- Critically ill patients treated with argatroban
- Participants
- 105 / 153 / 195
- Exposure
- Activated partial thromboplastin time (PTT), diluted thrombin time (TT) and point-of-care viscoelastic ecarin clotting time vs liquid chromatography with tandem mass spectrometry for argatroban quantification
- Diluted TTn = 105
- Ecarin clotting timen = 153
- Activated PTTn = 195
- Outcome
- Correlation of argatroban quantification with liquid chromatography with tandem mass spectrometry (Pearson r)
Main finding
As reported in the abstract
Correlation with liquid chromatography with tandem mass spectrometry
Diluted TT
0.91
Pearson r
Ecarin clotting time
0.58
Pearson r
Activated PTT
0.48
Pearson r
Observational data: associations, not effects.
Further findings
| Outcome | Coefficient (95% CrI) |
|---|---|
| Argatroban overdosing in patients with sepsis (Bayesian multilevel regression)CrI | 4.194 (2.220–6.792) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Monitoring of Argatroban in Critically Ill Patients: A Prospective Study Comparing Activated Partial Thromboplastin Time, Point-of-Care Viscoelastic Testing with Ecarin Clotting Time and Diluted Thrombin Time to Mass Spectrometry. Anesthesiology. Published 3 October 2023. doi:10.
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