Monitoring T-cell function in septic shock: one-year experience with a fully automated assay
Study context
- Population
- Patients with septic shock in the intensive care unit (ICU)
- Participants
- 66 patients
- Outcome
- T lymphocyte functionality: IFN-γ release in response to mitogen (IGRA, fully automated protocol)
Methodological detailssingle-center, Monitored 3 times during the first week after ICU admission; outcomes followed for 28 days
- Single-center
- Monitored 3 times during the first week after ICU admission; outcomes followed for 28 days
Main finding
As reported in the abstract
IFN-γ release capacity
- Significant reduction in IFN-γ release capacity vs reference values, correlated with characteristic alterations in cellular immunological parameters
Observational data: associations, not effects.
Further findings
Clinical deterioration (28-day mortality and/or ICU-acquired infection) · End of the first week
- Reduced IFN-γ release combined with low mHLA-DR identified a severe immunological phenotype associated with increased risk of clinical deterioration
Original publication
Monitoring T-cell function in septic shock: one-year experience with a fully automated assay. Crit Care. Published 9 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →