Cardiothoracic & vascular anesthesia
Morbidity and Mortality Associated With Blood Transfusions in Elective Adult Cardiac Surgery
Main finding · 30-day mortalityResult — go to the resultAdjusted odds ratio 0.95 95% CI 0.92–0.98Authors' conclusion
The present analysis found increasing HCT to be associated with a lower incidence of mortality. The study authors also found a direct dose-response association between transfusions and all study endpoints examined.
Study context
- Population
- Adults ≥18 years undergoing coronary artery bypass grafting (CABG) and/or valve surgery, 2013–2019, Academic Cardiac Surgery Consortium of 5 institutions>40% transfused ≥1 unit
- Participants
- 7,762 adults
- Exposure
- Perioperative packed red blood cell (pRBC) and coagulation product transfusions; preoperative HCT
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailsmulticentre, multivariate regression, machine learning models
- Multicentre
- Multivariate regression
- Machine learning models
Main finding
As reported in the abstract
Adjusted odds ratio
0.95
95% CI 0.92–0.98
Higher preoperative HCT
aOR 0.95 (95% CI 0.92–0.98)
Observational data: associations, not effects.
Further findings
Prolonged mechanical ventilation
| aOR (95% CI) | ||
|---|---|---|
| Higher preoperative HCT | 0.97 (0.95–0.99) | |
| 0.512Adjusted odds ratio (log scale) |
Machine learning (ML) prediction of 30-day mortality
- AUC
- 0.814-to-0.850
- Perioperative transfusions had highest feature importance
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Morbidity and Mortality Associated With Blood Transfusions in Elective Adult Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 17 November 2022. doi:10.
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