Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials
Pooled result · Short-term mortality and pooled mortality (longest period of data)Result — go to the resultRisk difference - 0.10 95% CI - 0.22 to 0.02Authors' conclusion
Administration of short-acting betablockers did not reduce short-term mortality in septic patients with persistent tachycardia.
Study context
- Population
- Adult septic patients
- Participants
- 854 patients · 7 RCTs
- Comparison
- Short-acting betablockers vs reference treatment
- Outcome
- Short-term mortality
Methodological detailsPRISMA
- PRISMA
Pooled result
As reported in the abstract
Short-term mortality and pooled mortality (longest period of data)
Risk difference
- 0.10
95% CI - 0.22 to 0.02
P = 0.11
Further pooled results
Short-term mortality by age (< 65 vs ≥ 65 years) (subgroup)
- No difference between patients aged < 65 vs ≥ 65 years
- P = 0.11
Short-term mortality by cardiac rhythm (sinus tachycardia vs AF) (subgroup)
- No difference between sinus tachycardia and AF
- P = 0.27
Publication bias
- No significant publication bias despite statistical heterogeneity
Original publication
Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials. Crit Care. Published 27 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →