Respiratory failure & ventilation
Multiplex Polymerase Chain Reaction Assay to Detect Nasopharyngeal Viruses in Immunocompromised Patients With Acute Respiratory Failure
Authors' conclusion
In immunocompromised patients with ARF, the results of nasopharyngeal multiplex PCR assays are not associated with IMV or mortality.
Study context
- Population
- Immunocompromised patients admitted to 32 ICUs for acute respiratory failure, May 2016–December 2017
- Participants
- 510 sampled patients
- Comparison
- Positive vs negative nasopharyngeal multiplex polymerase chain reaction (PCR) assay
- Primary endpoint
- Composite of:
- Day 28 mortality
- Invasive mechanical ventilation
- Both
- Follow-up
- Day 28
Methodological detailspreplanned post hoc analysis, multicentre, Causes of acute respiratory failure (ARF) reviewed by three expert investigators masked to multiplex PCR results
- Preplanned post hoc analysis
- Multicentre
- Causes of ARF reviewed by three expert investigators masked to multiplex PCR results
Primary result
As reported in the abstract
Composite of:
- Day 28 mortality
- IMV
- Both
P = 0.965
Further findings
Viral pneumonia as cause of ARF, by assay result — Flu-like viruses vs No virus detected · cause of ARF varied significantly across assay results
P < 0.001
Virus types detected (102 samples)
- Rhinoviruses or enteroviruses
- 35.5%
- Coronaviruses
- 10.9%
- Flu-like viruses (influenza, parainfluenza, RSV, human metapneumovirus)
- 52.7%
Composite outcome in allogeneic HSCT recipients (subgroup) · day 28
- Flu-like virus detection associated with higher rate of day 28 mortality, invasive mechanical ventilation (IMV), or both vs no detected virus
- Pre-established subgroup analysis
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Multiplex Polymerase Chain Reaction Assay to Detect Nasopharyngeal Viruses in Immunocompromised Patients With Acute Respiratory Failure. Chest. Published 9 August 2023. doi:10.
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