Perioperative medicine & outcomes
A Multivariable Model of the Association Between Postoperative Complications and 30-Day In-Hospital Mortality in the African Surgical Outcome Study Cohort
Authors' conclusion
In this African cohort, pulmonary embolism, pulmonary edema, and bloodstream infections were most strongly associated with death, while severe bloodstream infections accounted for the largest proportion of 30-day mortality.
Study context
- Population
- Adult perioperative patients in Africa, 2016
- Participants
- 10,748 patients
- Comparison
- Severe postoperative complications vs none
- Primary endpoint
- Association (adjusted OR) of severe postoperative complications with 30-day postoperative mortality and attributable fraction (AtF) of death for each complication
- Follow-up
- 30 days
Methodological detailslogistic mixed-effects model, adjusted for patient and surgical factors
- Logistic mixed-effects model
- Adjusted for patient and surgical factors
Primary result
As reported in the abstract
Adjusted OR for 30-day mortality, by severe complication
Odds ratio (95% CI)P value
Pulmonary embolism
484(85.2–2744)
P < 0.001Pulmonary edema
53.5(6.59–434)
P < 0.001Bloodstream infections
34.3(16.3–72.3)
P < 0.001- Highest attributable fraction (AtF) for 30-day mortality: severe bloodstream infections
- 13.7% (average AtF; 95% CI 10-18.1)
Further findings
30-day in-hospital mortality
- Died in hospital within 30 days postoperatively
- 222 (2.07%)
Original publication
A Multivariable Model of the Association Between Postoperative Complications and 30-Day In-Hospital Mortality in the African Surgical Outcome Study Cohort. Anesth Analg. Published 10 September 2026. doi:10.
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