Neural correlates of systemic lidocaine administration in healthy adults measured by functional MRI: a single arm open label study
Authors' conclusion
Lidocaine was associated with broad reductions in functional MRI response to acute pain and modulated whole-brain functional connectivity, predominantly decreasing long-range connectivity. This was accompanied by small but significant decreases in pain perception and memory performance.
Study context
- Population
- Healthy adults (age 22–55 yr)crossover: baseline then lidocaine
- Participants
- 27 adults
- Comparison
- Lidocaine vs baseline
- Outcome
- Group-level differences in pain task-evoked responses, focused on the insula, between baseline and lidocaine conditions
Main finding
As reported in the abstract
Pain-evoked responses in the insula
- Left insula: decreased with lidocaine, Z=3.6
- P<0.001
- Right insula: decreased with lidocaine, Z=3.6
- P=0.004
Further findings
Pain-evoked responses in other brain areas
- Decreased in cingulate gyrus, thalamus and primary sensory cortex with lidocaine
Resting-state connectivity
- Significant diffuse reductions in region-to-region and global connectivity with lidocaine
Pain intensity and unpleasantness
- Small decreases with lidocaine
Original publication
Neural correlates of systemic lidocaine administration in healthy adults measured by functional MRI: a single arm open label study. Br J Anaesth. Published 21 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →