Efficacy of systemic lidocaine versus ultrasound-guided adductor canal block for patients undergoing total knee arthroplasty: a randomized, double-blinded, non-inferiority study
Primary resultResult — go to the resultMedian difference 5.0 mg 95% CI −11.2 to 16.2Authors' conclusion
Continuous intravenous lidocaine was non-inferior to adductor canal block for postoperative analgesia at 24 hours after TKA.
Study context
- Population
- Patients undergoing outpatient total knee arthroplastyrandomised 1:1
- Participants
- 120 patients
- Comparison
- Lidocaine vs Adductor canal block
- Primary endpoint
- Opioid consumption (oral morphine equivalents); non-inferiority margin 30 mg OME
- Follow-up
- 24 hours after surgery
Methodological detailsdouble-blinded, non-inferiority
- Double-blinded
- Non-inferiority
Primary result
As reported in the abstract
24 hours
Median difference
5.0 mg
95% CI −11.2 to 16.2
By group
Lidocaine vs Adductor canal block
median difference 5.0 mg (95% CI −11.2 to 16.2)
Non-inferiority margin 30 as printed, not drawn
Secondary outcomes
| Outcome | Median difference (mg OME) (95% CI) | P value | |
|---|---|---|---|
| PACU opioid consumptionLower in the adductor canal block group | 10 (1.0–11.2) | P = 0.02 | |
| −5051015Difference, mg OME (linear scale) |
| Outcome | Median difference (points) (95% CI) | P value |
|---|---|---|
| Pain scores at PACU dischargeLower in the adductor canal block group | two (0.33–4) | P = 0.02 |
Time to first analgesic request, quality of recovery, patient satisfaction
- Similar between groups
Safety
- No study-related adverse events
Original publication
Efficacy of systemic lidocaine versus ultrasound-guided adductor canal block for patients undergoing total knee arthroplasty: a randomized, double-blinded, non-inferiority study. Reg Anesth Pain Med. Published 28 July 2026. doi:10.
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