Cardiac arrest & resuscitation

Neurological outcome of out-of-hospital cardiac arrest patients ventilated with continuous flow insufflation of oxygen: a multicenter observational study

ResuscitationPublished Multicentre observational cohort study

Main findingResult — go to the resultAdjusted odds ratio 0.61 95% CI 0.41–0.9

Authors' conclusion

The use of CFIO during OHCA was associated with significantly lower odds of favorable neurological outcome at day 30 compared to BVM.

Study context

Population
Adults with out-of-hospital cardiac arrest (OHCA) in three EMS systems, Northern French Alps Emergency Network cardiac arrest registry, 2017–2021
Participants
2,237 adults
Exposure
Continuous flow insufflation of oxygen (CFIO) vs bag-valve-mask (BVM)
  • CFIOn = 967
  • BVMn = 1,270reference
Outcome
Favorable neurological status (Cerebral Performance Category (CPC) 1 or 2)
Follow-up
30 days
Methodological detailsregistry-based, multivariable analysis
  • Registry-based
  • Multivariable analysis

Main finding

As reported in the abstract

Adjusted odds ratio

0.61

95% CI 0.41–0.9

P = 0.01

CFIO vs BVM
aOR 0.61 (95% CI 0.41–0.9); P = 0.01

Observational data: associations, not effects.

Original publication

Neurological outcome of out-of-hospital cardiac arrest patients ventilated with continuous flow insufflation of oxygen: a multicenter observational study. Resuscitation. Published 30 April 2026. doi:10.1016/j.resuscitation.2026.111113

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