Cardiothoracic & vascular anesthesia
Nitric Oxide to Reduce Acute Kidney Injury in Patients with Preexisting Endothelial Dysfunction Requiring Prolonged Cardiopulmonary Bypass: A Randomized Clinical Trial
Primary resultResult — go to the resultAdjusted odds ratio 1.00 95% CI 0.59–1.69Authors' conclusion
In cardiac surgery patients with preexisting endothelial dysfunction undergoing prolonged CPB, perioperative administration of 80 ppm nitric oxide for 24 h did not significantly reduce postoperative AKI.
Study context
- Population
- Adult cardiac surgery patients with preexisting endothelial dysfunction undergoing cardiopulmonary bypass (CPB) lasting more than 90 min
- Participants
- 250 patients
- Comparison
- Nitric oxide 80 ppm vs placebo for 24 h
- Nitric oxiden = 125
- Controln = 125reference
- Primary endpoint
- Incidence of postoperative AKI (KDIGO criteria)
Methodological detailsdouble-blind, single-centre, placebo-controlled
- Double-blind
- Single-centre
- Placebo-controlled
Primary result
As reported in the abstract
Adjusted odds ratio
1.00
95% CI 0.59–1.69
Events by treatment group
Nitric oxide vs Control
aOR 1.00 (95% CI 0.59–1.69)
Secondary outcomes
Acute kidney injury (AKI) severity (stage 1, 2 or 3) and RRT, during hospitalization and at 6 weeks, 90 days and 1 yr
- Similar between groups at all timepoints
Original publication
Nitric Oxide to Reduce Acute Kidney Injury in Patients with Preexisting Endothelial Dysfunction Requiring Prolonged Cardiopulmonary Bypass: A Randomized Clinical Trial. Anesthesiology. Published 21 November 2025. doi:10.
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