Cardiothoracic & vascular anesthesia
Effect of nitric oxide delivery via cardiopulmonary bypass circuit on postoperative oxygenation in adults undergoing cardiac surgery (NOCARD trial): a randomised controlled trial
Authors' conclusion
Patients with baseline hypoxaemia undergoing cardiac surgery and receiving nitric oxide exhibited lower hypoxaemia rates and higher p a O2 /FiO 2 ratios. No significant differences were found regarding postoperative pulmonary complications and overall outcomes.
Study context
- Population
- Adults scheduled for elective cardiac surgery, Rabin Medical Centre, Beilinson Hospital, Israelincluded in the final analysis
- Participants
- 98 adults
- Comparison
- Nitric oxide 40 ppm via CPB circuit vs no nitric oxide
- Nitric Oxiden = 51
- Controln = 47reference
- Primary endpoint
- Incidence of hypoxaemia (PaO2/FiO2 ratio less than 300)
- Follow-up
- Within 24 h postoperatively
Methodological detailsprospective, single-centre, double-blinded
- Prospective
- Single-centre
- Double-blinded
Primary result
As reported in the abstract
Hypoxaemia at admission to the cardiothoracic ICU · ICU admission
P = 0.043
Secondary outcomes
Hypoxaemia, patients with baseline hypoxaemia (subgroup) · admission to cardiothoracic ICU
P = 0.042
Hypoxaemia, patients without baseline hypoxaemia (subgroup)
- Benefit not observed
Low cardiac output syndrome and AKI · 72 h
- No significant differences
Safety
- No substantial safety concerns; toxic methaemoglobin levels not observed
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of nitric oxide delivery via cardiopulmonary bypass circuit on postoperative oxygenation in adults undergoing cardiac surgery (NOCARD trial): a randomised controlled trial. Eur J Anaesthesiol. Published 28 May 2024. doi:10.
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