Cardiothoracic & vascular anesthesia
Perioperative Nitric Oxide Conditioning Reduces Acute Kidney Injury in Cardiac Surgery Patients with Chronic Kidney Disease (the DEFENDER Trial): A Randomized Controlled Trial
Primary resultResult — go to the resultRelative risk 0.59 95% CI 0.35–0.99Authors' conclusion
Perioperative NO administration in CKD patients undergoing cardiac surgery with cardiopulmonary bypass is safe, reduces the incidence of AKI, and slows the progression of renal dysfunction.
Study context
- Population
- Patients with chronic kidney disease (CKD) undergoing elective cardiac surgery with CPB
- Participants
- 136 patients
- Comparison
- Perioperative nitric oxide (NO) vs sham treatment
- NOn = 68
- Controln = 68reference
- Primary endpoint
- Acute kidney injury (AKI) incidence
- Follow-up
- Within 7 days postsurgery
Methodological detailssham-controlled
- Sham-controlled
Primary result
As reported in the abstract
Relative risk
0.59
95% CI 0.35–0.99
P = 0.043
Events by treatment group
NO vs Control
RR 0.59 (95% CI 0.35–0.99); P = 0.043
Further findings
Glomerular filtration rate · Six months postsurgery
P = 0.038
| Outcome | NO | Control | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Postoperative pneumonia | 14.7% | 29.4% | 0.5 (0.25–0.99) | P = 0.039 | |
| 0.20.5125Relative risk (log scale) |
Safety
- Methemoglobin and nitrogen dioxide levels within acceptable ranges; oxidative-nitrosyl stress did not increase
- No significant differences in blood transfusion requirements, platelet counts or postoperative blood loss
Original publication
Perioperative Nitric Oxide Conditioning Reduces Acute Kidney Injury in Cardiac Surgery Patients with Chronic Kidney Disease (the DEFENDER Trial): A Randomized Controlled Trial. Anesthesiology. Published 9 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →