Hemodynamics, fluids & transfusion
Normosol-R vs Lactated Ringers in the Critically Ill: A Randomized Trial
Primary resultResult — go to the resultMean difference −0.12 mmol/dL 95% CI −0.61 to 0.36Authors' conclusion
Among critically ill adults, the use of Normosol-R for IV fluid therapy did not affect plasma HCO3- concentrations or clinical outcomes compared with lactated Ringers.
Study context
- Population
- Critically ill adults at an academic medical center in the USenrolled
- Participants
- 2,084 adults
- Comparison
- Normosol-R vs lactated Ringers
- Primary endpoint
- Plasma bicarbonate (HCO3-) concentration
- Follow-up
- Between enrollment and 7 days
Methodological detailspragmatic, cluster-randomized, multiple-crossover, single academic medical center, June 1, 2018, to January 31, 2019
- Pragmatic
- Cluster-randomized
- Multiple-crossover
- Single academic medical center
- June 1, 2018, to January 31, 2019
Primary result
As reported in the abstract
Mean difference
−0.12 mmol/dL
95% CI −0.61 to 0.36
P = 0.61
Normosol-R vs Lactated Ringers
mean difference −0.12 mmol/dL (95% CI −0.61 to 0.36); P = 0.61
Secondary outcomes
| Outcome | Normosol-R | Lactated Ringers | Absolute risk difference (95% CI) | |
|---|---|---|---|---|
| New kidney replacement therapy | 6.0% | 5.0% | 1.0% (−1.2% to 3.1%) | |
| Death · day 30 | 16.3% | 16.0% | 0.3% (−2.9% to 3.6%) | |
| −4−2024Difference (linear scale) |
Original publication
Normosol-R vs Lactated Ringers in the Critically Ill: A Randomized Trial. Chest. Published 17 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →