Cardiothoracic & vascular anesthesia
Novel inhaled pulmonary vasodilators in adult cardiac surgery: a scoping review
Authors' conclusion
The findings of this scoping review suggest that milrinone and levosimendan may be effective alternatives to current inhaled therapies for cardiac dysfunction in the setting of PH.
Study context
- Population
- Adult cardiac surgery patients with pulmonary hypertension
- Participants
- 969 patients · 17 studies
- Comparison
- Inhaled milrinone vs Inhaled levosimendan
Methodological detailsEmbase and MEDLINE searched, 1947 to 2022
- Embase and MEDLINE searched, 1947 to 2022
Main finding
As reported in the abstract
- Inhaled milrinone and levosimendan are selective pulmonary vasodilators with potential benefits from ease of weaning from CPB to reduction in ventricular dysfunction
- High-quality data limited; study design and comparators extremely heterogeneous
Original publication
Novel inhaled pulmonary vasodilators in adult cardiac surgery: a scoping review. Can J Anaesth. Published 23 May 2024. doi:10.
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