Respiratory failure & ventilation
Novel subgroups in acute respiratory failure based on the trajectories of three endotheliopathy biomarkers: A cohort study
Authors' conclusion
In ARF requiring mechanical ventilation, patients in subgroups with persistently high levels of sTM and PECAM-1 had lower rates of liberation from mechanical ventilation and higher 30-day mortality. However, patients with persistently high levels of sTM were identifiable based on the baseline level, and only the trajectory of PECAM-1 added information to that of the baseline level.
Study context
- Population
- Patients with acute respiratory failure requiring mechanical ventilation
- Participants
- 459 patients
- Comparison
- Subgroups by Days 1-3 trajectories of Syndecan-1, soluble Thrombomodulin (sTM) and PECAM-1
Methodological detailsexploratory, latent class mixed modeling
- Exploratory
- Latent class mixed modeling
Primary result
As reported in the abstract
Liberation from mechanical ventilation
high vs Group lowHazard ratio (95% CI)P value
sTM
0.66(0.50–0.88)
P = 0.01PECAM-1
0.59(0.37–0.93)
P = 0.02Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| 30-day mortality · 30 daysHigh vs Group low · sTM | 1.90 (1.20–3.01) | P = 0.01 | |
| 30-day mortality · 30 daysHigh vs Group low · PECAM-1 | 4.25 (1.99–9.07) | P < 0.01 | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Novel subgroups in acute respiratory failure based on the trajectories of three endotheliopathy biomarkers: A cohort study. Acta Anaesthesiol Scand. Published 12 April 2023. doi:10.
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