Obesity- and Lipid-Related Traits May Causally Contribute to Sepsis-Associated Acute Kidney Injury
Main finding · Genetic and causal associations with Septic-AKIResult — go to the resultOdds ratio 2.18Authors' conclusion
For Septic-AKI, GWAS identified a novel genetic susceptibility locus ( GALNTL6 ), which is also associated with cardiometabolic traits. We then further found that obesity- and lipid-related traits are possible contributors to the pathogenesis of Septic-AKI.
Study context
- Population
- Adults with sepsis or septic shock; U.K. Biobank, FinnGen, ICU septic shock cohorts (VASST, Chiba)replication: VASST n = 632, Chiba n = 536
- Participants
- 4,584 vs 7,090
- Comparison
- Septic-AKI cases vs sepsis without acute kidney injury (AKI) controls
- Septic-AKIn = 4,584
- Sepsis without AKIn = 7,090reference
- Outcome
- Genetic and causal associations with Septic-AKI
Methodological detailsnatural experiment and case-control study, two-sample Mendelian randomization (MR), discovery genome-wide association study (GWAS) in U.K. Biobank, replication in two independent septic shock cohorts, multiple ancestries
- Natural experiment and case-control study
- Two-sample MR
- Discovery GWAS in U.K. Biobank
- Replication in two independent septic shock cohorts
- Multiple ancestries
Main finding
As reported in the abstract
Odds ratio
2.18
P = 3.0 × 10 −8
Observational data: associations, not effects.
Further findings
- Increased BMI associated with increased serum creatinine in both septic shock cohorts
- P < 0.0001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Obesity- and Lipid-Related Traits May Causally Contribute to Sepsis-Associated Acute Kidney Injury. Crit Care Med. Published 14 August 2025. doi:10.
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