Onset time, duration of action, and intubating conditions after mivacurium in elderly and younger patients
Main finding · Onset timeResult — go to the resultDifference 16 s 95% CI −45 to 14Authors' conclusion
No difference in onset time of mivacurium 0.2 mg kg-1 was found comparing elderly and younger patients. However, elderly patients had significantly longer duration of action. No difference was found in intubating conditions.
Study context
- Population
- Elderly (≥80 years) and younger (18–40 years) adults given mivacurium for tracheal intubation under propofol-based GA
- Participants
- 35 vs 35
- Exposure
- Mivacurium 0.2 mg kg-1 in elderly vs younger patients
- Elderlyn = 35
- Youngern = 35reference
- Outcome
- Onset time (injection of mivacurium 0.2 mg kg-1 to train-of-four (TOF) count of zero)
Main finding
Onset time
Difference
16 s
95% CI −45 to 14
P = 0.30
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
min
| Outcome | Elderly | Younger | Difference (min) (95% CI) | P value | |
|---|---|---|---|---|---|
| Duration of action (time to TOF ratio ≥0.9) | 52 (SD 17) | 30 (SD 8) | 22 (15–28) | P < 0.001 | |
| −2002040Difference, min (linear scale) |
| Outcome | P value |
|---|---|
| Excellent intubating conditions (Fuchs-Buder)No difference | P = 0.12 |
| Intubating difficulty scale (IDS) scoreNo difference | P = 0.13 |
Intubating difficulty scale (IDS) score
- No difference in IDS score
Safety
Postoperative sore throat · 24 h
P = 0.0002
Hoarseness
- No difference between groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Onset time, duration of action, and intubating conditions after mivacurium in elderly and younger patients. Acta Anaesthesiol Scand. Published 19 May 2024. doi:10.
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