Onset timing and duration of augmented renal clearance in a mixed intensive care unit
Authors' conclusion
Despite the early onset of ARC, its duration varied widely and ARC persisted longer in younger patients with higher urinary CrCl.
Study context
- Population
- Critically ill patients admitted to the intensive care unit (ICU) of a tertiary emergency hospital, January 2019 to June 2022, with continuously measured urinary creatinine clearanceof 2592 ICU patients
- Participants
- 734 patients
- Outcome
- Onset timing and duration of augmented renal clearance (ARC)
Methodological detailssingle-centre, continuous monitoring of urinary creatinine clearance (CrCl)
- Single-centre
- Continuous monitoring of urinary CrCl
Main finding
As reported in the abstract
ARC prevalence, onset and duration
Prevalence of augmented renal clearance (ARC)
33.4%
245/734
Duration of ARC (median; varied widely, >1 month in some cases)
5 days
Observational data: associations, not effects.
Further findings
Factors associated with ARC onset (multivariate analysis)
- Younger age, male sex, lower serum creatinine at admission, admission with central nervous system disease, no medical history, mechanically assisted ventilation, vasopressor use
Factors associated with ARC persistence
- Younger age and higher urinary CrCl on ARC day 1
Clinical outcomes
- ARC onset significantly associated with reduced mortality
- ARC persistence significantly associated with fewer ICU-free days
Original publication
Onset timing and duration of augmented renal clearance in a mixed intensive care unit. J Intensive Care. Published 23 March 2023. doi:10.
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