Optimal local anesthetic for spinal anesthesia in patients undergoing ambulatory non-arthroplasty surgery: a systematic review and Bayesian network meta-analysis of randomized controlled trials
Authors' conclusion
Evidence supports 2-chloroprocaine for short-duration spinal anesthesia in the ambulatory setting.
Study context
- Population
- Adults undergoing ambulatory (daycare) non-arthroplasty surgery under spinal anaesthesia, mostly knee arthroscopy
- Participants
- 3,299 adults · 44 trials
- Comparison
- 11 local anaesthetic agents/doses for spinal anaesthesia
- Outcome
- Time to discharge
Methodological detailsConfidence in Network Meta-Analysis (CINeMA) certainty assessment, SUCRA ranking
- CINeMA certainty assessment
- SUCRA ranking
Pooled result
As reported in the abstract
Discharge readiness
- 2-chloroprocaine, lidocaine and mepivacaine superior for discharge readiness
- Low- to moderate-certainty evidence
Further pooled results
Sensory and motor block duration, time to first ambulation, spontaneous voiding
- 2-chloroprocaine ranked highest
Original publication
Optimal local anesthetic for spinal anesthesia in patients undergoing ambulatory non-arthroplasty surgery: a systematic review and Bayesian network meta-analysis of randomized controlled trials. Can J Anaesth. Published 8 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →