Hemodynamics, fluids & transfusion
Orthostatic intolerance after acute mild hypovolemia: incidence, pathophysiologic hemodynamics, and heart-rate variability analysis—a prospective observational cohort study
Authors' conclusion
We describe a specific hypovolemic component of postoperative OI, independent of postoperative autonomic dysfunction, inflammation, opioids, and pain.
Study context
- Population
- Blood donors (mild acute blood loss simulating postoperative hypovolemia)
- Participants
- 26 blood donors
- Exposure
- Before vs 15 min after blood donation
- Outcome
- Incidence of orthostatic intolerance (OI) during mobilization
- Follow-up
- 15 min after blood donation
Main finding
As reported in the abstract
Orthostatic intolerance during mobilization
After donation
23%
6/26 events
Observational data: associations, not effects.
Further findings
Premature termination of mobilization because of severe orthostatic intolerance (OI) symptoms, after donation
- Donors terminating mobilization prematurely
- 3/26 (12%) (95% CI 2 to 30)
Cardiovascular and cerebral tissue oxygenation responses in severe OI
- Reduced in patients with severe OI
Heart rate variability (HRV) after blood loss, during mobilization and sleep
- Total autonomic power unchanged; increased sympathetic and decreased parasympathetic outflow during mobilization and sleep
Original publication
Orthostatic intolerance after acute mild hypovolemia: incidence, pathophysiologic hemodynamics, and heart-rate variability analysis—a prospective observational cohort study. Can J Anaesth. Published 26 September 2023. doi:10.
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