Pediatric anesthesia & critical care
Outcomes and characteristics of cardiac arrest in children with pulmonary hypertension: A secondary analysis of the ICU-RESUS clinical trial
Primary result · Survival with favorable neurologic outcomeResult — go to the resultAdjusted odds ratio 0.82 95% CI 0.56–1.20Authors' conclusion
In this prospective study of pediatric IHCA, pre-existing PH was present in 16% of children. Pre-arrest PH diagnosis was not associated with statistically significant differences in survival outcomes or intra-arrest physiologic measures.
Study context
- Population
- Children with in-hospital cardiac arrest (IHCA) in the ICU
- Participants
- 1,129 index IHCAs
- Comparison
- Pre-arrest pulmonary hypertension (PH) diagnosis vs no PH
- PHn = 184
- Primary endpoint
- Survival to hospital discharge with favorable neurologic outcome (PCPC 1-3 or unchanged from baseline); primary physiologic outcome: event-level average DBP during CPR
- Follow-up
- Hospital discharge
Methodological detailsprospectively designed
- Prospectively designed
Primary result
Survival with favorable neurologic outcome
Adjusted odds ratio
0.82
95% CI 0.56–1.20
P = 0.32
By group
PH vs No PH
aOR 0.82 (95% CI 0.56–1.20); P = 0.32
As reported in the abstract
Further findings
- Prevalence of PH
- 16.3% · 184
CPR event outcome, survival to hospital discharge
- No significant differences
SBP and end-tidal CO2 during CPR
- Similar between groups
Original publication
Outcomes and characteristics of cardiac arrest in children with pulmonary hypertension: A secondary analysis of the ICU-RESUS clinical trial. Resuscitation. Published 3 July 2023. doi:10.
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