Cardiac arrest & resuscitation
Oxygen Saturation Targets and Neurologic Outcomes Following Cardiac Arrest: A Secondary Analysis of the Pragmatic Investigation of Optimal Oxygen Targets Trial
Primary resultResult — go to the resultAbsolute risk difference 9.9 percentage points 95% CI 1.8–18.1Authors' conclusion
Among patients receiving mechanical ventilation following a cardiac arrest, use of a lower or intermediate Spo2 target was associated with a higher incidence of a favorable neurologic outcome compared with a higher target.
Study context
- Population
- Mechanically ventilated critically ill adults in the PILOT trial who had a cardiac arrest before enrollmentof 2,987 PILOT patients
- Participants
- 339 participants
- Comparison
- Lower or intermediate SpO2 target vs higher SpO2 target
- Lower or intermediaten = 221
- Highern = 118reference
- Primary endpoint
- Survival with a favorable neurologic outcome (Cerebral Performance Category 1 or 2)
- Follow-up
- Hospital discharge
Methodological detailssubgroup analysis, pragmatic
- Subgroup analysis
- Pragmatic
Primary result
As reported in the abstract
Absolute risk difference
9.9 percentage points
95% CI 1.8–18.1
P = 0.03
Events by treatment group
Lower or intermediate vs Higher
absolute risk difference 9.9 percentage points (95% CI 1.8–18.1); P = 0.03
Original publication
Oxygen Saturation Targets and Neurologic Outcomes Following Cardiac Arrest: A Secondary Analysis of the Pragmatic Investigation of Optimal Oxygen Targets Trial. Chest. Published 30 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →