Pain intensity and opioid consumption after temporary and permanent peripheral nerve stimulation: a 2-year multicenter analysis
Authors' conclusion
This study found that both temporary and permanent PNS may be effective for reducing pain intensity in patients with chronic pain up to 24 months postimplantation, although no changes in opioid consumption were observed. The decrease in pain intensity was comparable between patients receiving temporary versus permanent implants, highlighting that temporary PNS may achieve long-lasting clinical benefits.
Study context
- Population
- Patients with chronic pain who received peripheral nerve stimulation (PNS) implants at a multicentre enterprise, January 1, 2014 to February 24, 2022included in analysis
- Participants
- 126 patients
- Exposure
- Temporary vs permanent peripheral nerve stimulation
- Outcome
- Co-primary: (1) change in pain intensity (11-point NRS) from baseline; (2) comparison of this change between temporary and permanent PNS
- Follow-up
- 12 months postimplant
Methodological detailsmulticentre, co-primary outcomes
- Multicentre
- Co-primary outcomes
Main finding
As reported in the abstract
Change in pain intensity (NRS) from baseline
MD (95% CI)P value
Overall cohortchange from baseline
−3.0(−3.5 to −2.4)
P < 0.0001Temporary PNS vs Permanent PNSno significant difference in reduction
0.0(−1.1 to 1.0)
P = 1.00Observational data: associations, not effects.
Further findings
Pain intensity, overall, temporary and permanent cohorts · 3, 6 and 24 months
- Significantly decreased in all cohorts at all secondary time points
Daily opioid consumption, overall cohort · 6 and 12 months postimplant
- No change observed
Original publication
Pain intensity and opioid consumption after temporary and permanent peripheral nerve stimulation: a 2-year multicenter analysis. Reg Anesth Pain Med. Published 26 July 2024. doi:10.
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