Respiratory failure & ventilation
Parasternal intercostal thickening at hospital admission: a promising indicator for mechanical ventilation risk in subjects with severe COVID-19
Authors' conclusion
In subjects with severe COVID-19, PIC TF of 8.3% can predict the need to ventilatory support with a positive predictive value of 90-100%. PIC TF is an independent risk factor for the need for invasive mechanical ventilation and/or 30-days mortality.
Study context
- Population
- Adults with severe COVID-19, data collected within 12 h of admissionavailable for final evaluation
- Participants
- 50 adults
- Exposure
- Right vs left PIC TF for predicting need for ventilatory support
- Outcome
- Need for ventilatory support
Main finding
As reported in the abstract
| Group | AUC (95% CI) |
|---|---|
| Right PIC TF | 0.94 (0.83-0.99) |
| Left PIC TF | 0.94 (0.84-0.99) |
AUC (95% CI)
Right PIC TF0.94 (0.83-0.99)
Left PIC TF0.94 (0.84-0.99)
- Cut-off value
- > 8.3%
- PPV
- 90-100%
Observational data: associations, not effects.
Further findings
| Outcome | Right PIC TF | Left PIC TF |
|---|---|---|
| Invasive mechanical ventilation and/or 30-day mortality (composite) | ||
| AUC | 0.95 (0.85-0.99) | 0.90 (0.78-0.97) |
Invasive mechanical ventilation and/or 30-day mortality (composite)
- In multivariate analysis, only PIC TF independently predicted invasive mechanical ventilation and/or 30-day mortality
Original publication
Parasternal intercostal thickening at hospital admission: a promising indicator for mechanical ventilation risk in subjects with severe COVID-19. J Clin Monit Comput. Published 24 March 2023. doi:10.
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